Skin redness after Ivermectin + Pyrantel (Heartgard Plus) in dogs

491 reports to the FDA describe skin redness in dogs given Ivermectin + Pyrantel. That is 0.3% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported less often than average with this medicine.

491Reports

56%Marked serious

30%Recovered

2.4%Died or euthanised

3 daysTypical onset

How soon it started

Same day

101 34%

1–2 days

46 15%

3–7 days

21 7.0%

1–4 weeks

29 9.6%

Over a month

104 35%

How the animals did

Recovered

137 28%

Recovered with lasting effects

9 1.8%

Still unwell when reported

70 14%

Died

5 1.0%

Euthanised

7 1.4%

Not known

263 54%

Problems reported at the same time

195 40%

80 16%

69 14%

67 14%

61 12%

59 12%

Skin rash or irritation

57 12%

Hair loss

55 11%

Age of the animals

Under 1 year

1–3 years

136

4–7 years

147

8–11 years

12+ years

About this medicine

Ivermectin prevents heartworm disease (monthly). Pyrantel treats roundworms and hookworms.

Products with this combination include Heartgard Plus, Tri-Heart Plus, Iverhart Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Pyrantel cause skin redness in dogs?: 491 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin redness with similar medicines

Skin redness after Milbemycin Oxime + Spinosad (Trifexis) 828 reports · 0.6% of its reports
Skin redness after Moxidectin (ProHeart 6) 1,035 reports · 2.0% of its reports
Skin redness after Milbemycin Oxime + Praziquantel (Interceptor Plus) 163 reports · 0.5% of its reports
Skin redness after Milbemycin Oxime (Interceptor) 71 reports · 0.2% of its reports
Skin redness after Selamectin (Revolution) 365 reports · 1.2% of its reports
Skin redness after Ivermectin (Heartgard) 105 reports · 0.9% of its reports
Skin redness after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 24 reports · 2.1% of its reports

All reported side effects of Ivermectin + Pyrantel in dogs · Medicines most reported with skin redness