Skin redness after Moxidectin (ProHeart 6) in dogs

The FDA has received 1,035 reports of skin redness in dogs after Moxidectin. That is 2.0% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

1,035Reports

50%Marked serious

41%Recovered

2.2%Died or euthanised

Same dayTypical onset

How soon it started

Same day

830 87%

1–2 days

43 4.5%

3–7 days

28 2.9%

1–4 weeks

27 2.8%

Over a month

29 3.0%

How the animals did

Recovered

424 41%

Recovered with lasting effects

2 0.2%

Still unwell when reported

492 48%

Died

13 1.3%

Euthanised

10 1.0%

Not known

94 9.1%

Problems reported at the same time

679 66%

555 54%

484 47%

266 26%

198 19%

151 15%

107 10%

101 9.8%

Age of the animals

Under 1 year

1–3 years

581

4–7 years

250

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause skin redness in dogs?: 1,035 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin redness with similar medicines

Skin redness after Ivermectin + Pyrantel (Heartgard Plus) 491 reports · 0.3% of its reports
Skin redness after Milbemycin Oxime + Spinosad (Trifexis) 828 reports · 0.6% of its reports
Skin redness after Milbemycin Oxime + Praziquantel (Interceptor Plus) 163 reports · 0.5% of its reports
Skin redness after Milbemycin Oxime (Interceptor) 71 reports · 0.2% of its reports
Skin redness after Selamectin (Revolution) 365 reports · 1.2% of its reports
Skin redness after Ivermectin (Heartgard) 105 reports · 0.9% of its reports
Skin redness after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 24 reports · 2.1% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with skin redness