Skin redness after Milbemycin Oxime (Interceptor) in dogs

The FDA has received 71 reports of skin redness in dogs after Milbemycin Oxime. That is 0.2% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported less often than average with this medicine.

71Reports

28%Marked serious

37%Recovered

4.2%Died or euthanised

9 daysTypical onset

How soon it started

Same day

8 29%

1–2 days

4 14%

3–7 days

1 3.6%

1–4 weeks

6 21%

Over a month

9 32%

How the animals did

Recovered

25 35%

Recovered with lasting effects

1 1.4%

Still unwell when reported

13 18%

Died

3 4.2%

Not known

29 41%

Problems reported at the same time

25 35%

14 20%

12 17%

12 17%

12 17%

11 15%

10 14%

Skin rash or irritation

10 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause skin redness in dogs?: 71 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 9 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin redness with similar medicines

Skin redness after Ivermectin + Pyrantel (Heartgard Plus) 491 reports · 0.3% of its reports
Skin redness after Milbemycin Oxime + Spinosad (Trifexis) 828 reports · 0.6% of its reports
Skin redness after Moxidectin (ProHeart 6) 1,035 reports · 2.0% of its reports
Skin redness after Milbemycin Oxime + Praziquantel (Interceptor Plus) 163 reports · 0.5% of its reports
Skin redness after Selamectin (Revolution) 365 reports · 1.2% of its reports
Skin redness after Ivermectin (Heartgard) 105 reports · 0.9% of its reports
Skin redness after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 24 reports · 2.1% of its reports

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with skin redness