Skin redness after Milbemycin Oxime + Praziquantel (Interceptor Plus) in dogs

163 reports to the FDA describe skin redness in dogs given Milbemycin Oxime + Praziquantel. That is 0.5% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported less often than average with this medicine.

163Reports

26%Marked serious

28%Recovered

2.5%Died or euthanised

29 daysTypical onset

How soon it started

Same day

21 18%

1–2 days

15 13%

3–7 days

9 7.8%

1–4 weeks

13 11%

Over a month

57 50%

How the animals did

Recovered

46 28%

Still unwell when reported

55 34%

Died

2 1.2%

Euthanised

2 1.2%

Not known

58 36%

Problems reported at the same time

41 25%

33 20%

28 17%

23 14%

20 12%

Skin rash or irritation

19 12%

Diarrhea

19 12%

Allergic reaction

19 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Praziquantel cause skin redness in dogs?: 163 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 29 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin redness with similar medicines

Skin redness after Ivermectin + Pyrantel (Heartgard Plus) 491 reports · 0.3% of its reports
Skin redness after Milbemycin Oxime + Spinosad (Trifexis) 828 reports · 0.6% of its reports
Skin redness after Moxidectin (ProHeart 6) 1,035 reports · 2.0% of its reports
Skin redness after Milbemycin Oxime (Interceptor) 71 reports · 0.2% of its reports
Skin redness after Selamectin (Revolution) 365 reports · 1.2% of its reports
Skin redness after Ivermectin (Heartgard) 105 reports · 0.9% of its reports
Skin redness after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 24 reports · 2.1% of its reports

All reported side effects of Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with skin redness