Recumbency after Selamectin (Revolution) in dogs

The FDA has received 67 reports of recumbency in dogs after Selamectin. That is 0.2% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

67Reports
9.0%Marked serious
3.0%Recovered
43%Died or euthanised
–Typical onset
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How the animals did

Recovered
2 3.0%
Still unwell when reported
2 3.0%
Died
29 43%
Not known
34 51%

Problems reported at the same time

Age of the animals

Under 1 year
19
1–3 years
7
4–7 years
17
8–11 years
9
12+ years
15

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause recumbency in dogs?
67 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Recumbency with similar medicines

All reported side effects of Selamectin in dogs · Medicines most reported with recumbency