Hind limb paresis after Selamectin (Revolution) in dogs

65 reports to the FDA describe hind limb paresis in dogs given Selamectin. That is 0.2% of all reports for this medicine, compared with 0.3% across reports for all dog medicines.

65Reports

11%Marked serious

3.1%Recovered

11%Died or euthanised

5 daysTypical onset

How soon it started

Same day

2 18%

1–2 days

3 27%

3–7 days

2 18%

1–4 weeks

2 18%

Over a month

2 18%

How the animals did

Recovered

2 3.1%

Still unwell when reported

9 14%

Died

7 11%

Not known

47 72%

Problems reported at the same time

20 31%

16 25%

15 23%

11 17%

8 12%

8 12%

7 11%

7 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause hind limb paresis in dogs?: 65 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 5 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hind limb paresis with similar medicines

Hind limb paresis after Ivermectin + Pyrantel (Heartgard Plus) 151 reports · 0.1% of its reports
Hind limb paresis after Milbemycin Oxime + Spinosad (Trifexis) 91 reports · 0.1% of its reports
Hind limb paresis after Moxidectin (ProHeart 6) 173 reports · 0.3% of its reports
Hind limb paresis after Milbemycin Oxime + Praziquantel (Interceptor Plus) 26 reports · 0.1% of its reports
Hind limb paresis after Milbemycin Oxime (Interceptor) 50 reports · 0.2% of its reports
Hind limb paresis after Ivermectin (Heartgard) 49 reports · 0.4% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with hind limb paresis