Hind limb paresis after Milbemycin Oxime (Interceptor) in dogs

50 reports to the FDA describe hind limb paresis in dogs given Milbemycin Oxime. That is 0.2% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

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How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause hind limb paresis in dogs?

50 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hind limb paresis with similar medicines

• Hind limb paresis after Ivermectin + Pyrantel (Heartgard Plus) 151 reports · 0.1% of its reports
• Hind limb paresis after Milbemycin Oxime + Spinosad (Trifexis) 91 reports · 0.1% of its reports
• Hind limb paresis after Moxidectin (ProHeart 6) 173 reports · 0.3% of its reports
• Hind limb paresis after Milbemycin Oxime + Praziquantel (Interceptor Plus) 26 reports · 0.1% of its reports
• Hind limb paresis after Selamectin (Revolution) 65 reports · 0.2% of its reports
• Hind limb paresis after Ivermectin (Heartgard) 49 reports · 0.4% of its reports

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with hind limb paresis