Hind limb paresis after Milbemycin Oxime + Praziquantel (Interceptor Plus) in dogs
The FDA has received 26 reports of hind limb paresis in dogs after Milbemycin Oxime + Praziquantel. That is 0.1% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported less often than average with this medicine.
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.
Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Milbemycin Oxime + Praziquantel cause hind limb paresis in dogs?
- 26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Hind limb paresis with similar medicines
- Hind limb paresis after Ivermectin + Pyrantel (Heartgard Plus) 151 reports · 0.1% of its reports
- Hind limb paresis after Milbemycin Oxime + Spinosad (Trifexis) 91 reports · 0.1% of its reports
- Hind limb paresis after Moxidectin (ProHeart 6) 173 reports · 0.3% of its reports
- Hind limb paresis after Milbemycin Oxime (Interceptor) 50 reports · 0.2% of its reports
- Hind limb paresis after Selamectin (Revolution) 65 reports · 0.2% of its reports
- Hind limb paresis after Ivermectin (Heartgard) 49 reports · 0.4% of its reports
All reported side effects of Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with hind limb paresis