Proprioception abnormality after Milbemycin Oxime (Interceptor) in dogs
The FDA has received 26 reports of proprioception abnormality in dogs after Milbemycin Oxime. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines.
26Reports
3.8%Marked serious
3.8%Recovered
12%Died or euthanised
–Typical onset
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How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).
Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Milbemycin Oxime cause proprioception abnormality in dogs?
- 26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Proprioception abnormality with similar medicines
- Proprioception abnormality after Ivermectin + Pyrantel (Heartgard Plus) 30 reports · 0.0% of its reports
- Proprioception abnormality after Milbemycin Oxime + Spinosad (Trifexis) 24 reports · 0.0% of its reports
- Proprioception abnormality after Moxidectin (ProHeart 6) 57 reports · 0.1% of its reports
- Proprioception abnormality after Selamectin (Revolution) 22 reports · 0.1% of its reports
All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with proprioception abnormality