Excessive urination after Selamectin (Revolution) in dogs

The FDA has received 93 reports of excessive urination in dogs after Selamectin. That is 0.3% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported less often than average with this medicine.

93Reports

12%Marked serious

5.4%Recovered

11%Died or euthanised

16 daysTypical onset

How soon it started

Same day

6 27%

1–2 days

2 9.1%

3–7 days

0 0.0%

1–4 weeks

7 32%

Over a month

7 32%

How the animals did

Recovered

5 5.4%

Still unwell when reported

16 17%

Died

7 7.5%

Euthanised

3 3.2%

Not known

62 67%

Problems reported at the same time

Excessive thirst

77 83%

Loss of appetite

28 30%

Lethargy

26 28%

Decreased urine concentration

17 18%

17 18%

16 17%

16 17%

12 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause excessive urination in dogs?: 93 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 16 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive urination with similar medicines

Excessive urination after Ivermectin + Pyrantel (Heartgard Plus) 198 reports · 0.1% of its reports
Excessive urination after Milbemycin Oxime + Spinosad (Trifexis) 270 reports · 0.2% of its reports
Excessive urination after Moxidectin (ProHeart 6) 245 reports · 0.5% of its reports
Excessive urination after Milbemycin Oxime + Praziquantel (Interceptor Plus) 99 reports · 0.3% of its reports
Excessive urination after Milbemycin Oxime (Interceptor) 92 reports · 0.3% of its reports
Excessive urination after Ivermectin (Heartgard) 60 reports · 0.5% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with excessive urination