Excessive urination after Milbemycin Oxime (Interceptor) in dogs

92 reports to the FDA describe excessive urination in dogs given Milbemycin Oxime. That is 0.3% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported less often than average with this medicine.

92Reports

24%Marked serious

8.7%Recovered

5.4%Died or euthanised

66 daysTypical onset

How soon it started

Same day

5 24%

1–2 days

4 19%

3–7 days

0 0.0%

1–4 weeks

0 0.0%

Over a month

12 57%

How the animals did

Recovered

8 8.7%

Still unwell when reported

12 13%

Died

1 1.1%

Euthanised

4 4.3%

Not known

67 73%

Problems reported at the same time

66 72%

22 24%

21 23%

15 16%

Decreased urine concentration

15 16%

Diarrhea

14 15%

Liver problems

14 15%

Kidney problems

11 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause excessive urination in dogs?: 92 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 66 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive urination with similar medicines

Excessive urination after Ivermectin + Pyrantel (Heartgard Plus) 198 reports · 0.1% of its reports
Excessive urination after Milbemycin Oxime + Spinosad (Trifexis) 270 reports · 0.2% of its reports
Excessive urination after Moxidectin (ProHeart 6) 245 reports · 0.5% of its reports
Excessive urination after Milbemycin Oxime + Praziquantel (Interceptor Plus) 99 reports · 0.3% of its reports
Excessive urination after Selamectin (Revolution) 93 reports · 0.3% of its reports
Excessive urination after Ivermectin (Heartgard) 60 reports · 0.5% of its reports

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with excessive urination