Excessive urination after Moxidectin (ProHeart 6) in dogs

The FDA has received 245 reports of excessive urination in dogs after Moxidectin. That is 0.5% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported less often than average with this medicine.

245Reports

33%Marked serious

4.9%Recovered

18%Died or euthanised

2 daysTypical onset

How soon it started

Same day

51 34%

1–2 days

31 20%

3–7 days

18 12%

1–4 weeks

25 16%

Over a month

27 18%

How the animals did

Recovered

12 4.9%

Still unwell when reported

123 50%

Died

33 13%

Euthanised

11 4.5%

Not known

66 27%

Problems reported at the same time

198 81%

84 34%

81 33%

63 26%

59 24%

47 19%

45 18%

39 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause excessive urination in dogs?: 245 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive urination with similar medicines

Excessive urination after Ivermectin + Pyrantel (Heartgard Plus) 198 reports · 0.1% of its reports
Excessive urination after Milbemycin Oxime + Spinosad (Trifexis) 270 reports · 0.2% of its reports
Excessive urination after Milbemycin Oxime + Praziquantel (Interceptor Plus) 99 reports · 0.3% of its reports
Excessive urination after Milbemycin Oxime (Interceptor) 92 reports · 0.3% of its reports
Excessive urination after Selamectin (Revolution) 93 reports · 0.3% of its reports
Excessive urination after Ivermectin (Heartgard) 60 reports · 0.5% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with excessive urination