Weight loss after Moxidectin (ProHeart 6) in dogs

858 reports to the FDA describe weight loss in dogs given Moxidectin. That is 1.7% of all reports for this medicine, compared with 1.7% across reports for all dog medicines.

858Reports

41%Marked serious

2.4%Recovered

26%Died or euthanised

4 daysTypical onset

How soon it started

Same day

120 26%

1–2 days

90 19%

3–7 days

68 15%

1–4 weeks

70 15%

Over a month

114 25%

How the animals did

Recovered

18 2.1%

Recovered with lasting effects

3 0.3%

Still unwell when reported

379 44%

Died

151 18%

Euthanised

69 8.0%

Not known

238 28%

Problems reported at the same time

470 55%

395 46%

331 39%

223 26%

222 26%

200 23%

167 19%

128 15%

Age of the animals

Under 1 year

1–3 years

213

4–7 years

299

8–11 years

216

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause weight loss in dogs?: 858 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 4 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Weight loss with similar medicines

Weight loss after Ivermectin + Pyrantel (Heartgard Plus) 889 reports · 0.6% of its reports
Weight loss after Milbemycin Oxime + Spinosad (Trifexis) 1,989 reports · 1.5% of its reports
Weight loss after Milbemycin Oxime + Praziquantel (Interceptor Plus) 515 reports · 1.6% of its reports
Weight loss after Milbemycin Oxime (Interceptor) 348 reports · 1.2% of its reports
Weight loss after Selamectin (Revolution) 230 reports · 0.8% of its reports
Weight loss after Ivermectin (Heartgard) 200 reports · 1.7% of its reports
Weight loss after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 42 reports · 0.5% of its reports
Weight loss after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 29 reports · 2.5% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with weight loss