Decreased urine concentration after Selamectin (Revolution) in dogs

47 reports to the FDA describe decreased urine concentration in dogs given Selamectin. That is 0.2% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

47Reports
15%Marked serious
2.1%Recovered
15%Died or euthanised
–Typical onset
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How the animals did

Recovered
1 2.1%
Still unwell when reported
6 13%
Died
6 13%
Euthanised
1 2.1%
Not known
33 70%

Problems reported at the same time

Kidney problems
24 51%
Loss of appetite
22 47%
Excessive thirst
20 43%
Lethargy
18 38%
Liver problems
18 38%
Vomiting
17 36%
Excessive urination
17 36%
Hyperphosphataemia
10 21%

Age of the animals

Under 1 year
6
1–3 years
11
4–7 years
9
8–11 years
13
12+ years
8

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause decreased urine concentration in dogs?
47 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Decreased urine concentration with similar medicines

All reported side effects of Selamectin in dogs · Medicines most reported with decreased urine concentration