Adipsia after Selamectin (Revolution) in dogs

The FDA has received 67 reports of adipsia in dogs after Selamectin. That is 0.2% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

67Reports

22%Marked serious

21%Recovered

21%Died or euthanised

Same dayTypical onset

How soon it started

Same day

18 51%

1–2 days

10 29%

3–7 days

2 5.7%

1–4 weeks

5 14%

Over a month

0 0.0%

How the animals did

Recovered

14 21%

Still unwell when reported

10 15%

Died

9 13%

Euthanised

5 7.5%

Not known

29 43%

Problems reported at the same time

59 88%

54 81%

19 28%

13 19%

11 16%

11 16%

9 13%

8 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause adipsia in dogs?: 67 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Adipsia with similar medicines

Adipsia after Ivermectin + Pyrantel (Heartgard Plus) 198 reports · 0.1% of its reports
Adipsia after Milbemycin Oxime + Spinosad (Trifexis) 501 reports · 0.4% of its reports
Adipsia after Moxidectin (ProHeart 6) 147 reports · 0.3% of its reports
Adipsia after Milbemycin Oxime + Praziquantel (Interceptor Plus) 37 reports · 0.1% of its reports
Adipsia after Milbemycin Oxime (Interceptor) 48 reports · 0.2% of its reports
Adipsia after Ivermectin (Heartgard) 48 reports · 0.4% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with adipsia