Adipsia after Moxidectin (ProHeart 6) in dogs

147 reports to the FDA describe adipsia in dogs given Moxidectin. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

147Reports

40%Marked serious

9.5%Recovered

21%Died or euthanised

1 daysTypical onset

How soon it started

Same day

42 41%

1–2 days

31 30%

3–7 days

11 11%

1–4 weeks

13 13%

Over a month

6 5.8%

How the animals did

Recovered

14 9.5%

Still unwell when reported

67 46%

Died

20 14%

Euthanised

11 7.5%

Not known

35 24%

Problems reported at the same time

138 94%

88 60%

41 28%

32 22%

27 18%

27 18%

26 18%

24 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause adipsia in dogs?: 147 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Adipsia with similar medicines

Adipsia after Ivermectin + Pyrantel (Heartgard Plus) 198 reports · 0.1% of its reports
Adipsia after Milbemycin Oxime + Spinosad (Trifexis) 501 reports · 0.4% of its reports
Adipsia after Milbemycin Oxime + Praziquantel (Interceptor Plus) 37 reports · 0.1% of its reports
Adipsia after Milbemycin Oxime (Interceptor) 48 reports · 0.2% of its reports
Adipsia after Selamectin (Revolution) 67 reports · 0.2% of its reports
Adipsia after Ivermectin (Heartgard) 48 reports · 0.4% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with adipsia