Adipsia after Milbemycin Oxime (Interceptor) in dogs

48 reports to the FDA describe adipsia in dogs given Milbemycin Oxime. That is 0.2% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

48Reports

21%Marked serious

13%Recovered

17%Died or euthanised

26 daysTypical onset

How soon it started

Same day

2 17%

1–2 days

3 25%

3–7 days

0 0.0%

1–4 weeks

2 17%

Over a month

5 42%

How the animals did

Recovered

6 13%

Still unwell when reported

3 6.3%

Died

7 15%

Euthanised

1 2.1%

Not known

31 65%

Problems reported at the same time

40 83%

33 69%

17 35%

9 19%

8 17%

8 17%

5 10%

4 8.3%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause adipsia in dogs?: 48 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 26 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Adipsia with similar medicines

Adipsia after Ivermectin + Pyrantel (Heartgard Plus) 198 reports · 0.1% of its reports
Adipsia after Milbemycin Oxime + Spinosad (Trifexis) 501 reports · 0.4% of its reports
Adipsia after Moxidectin (ProHeart 6) 147 reports · 0.3% of its reports
Adipsia after Milbemycin Oxime + Praziquantel (Interceptor Plus) 37 reports · 0.1% of its reports
Adipsia after Selamectin (Revolution) 67 reports · 0.2% of its reports
Adipsia after Ivermectin (Heartgard) 48 reports · 0.4% of its reports

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with adipsia