Urinary incontinence after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 187 reports of urinary incontinence in dogs after Pyrantel + Sarolaner. That is 0.4% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported less often than average with this medicine.

187Reports
61%Marked serious
26%Recovered
9.1%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
66 38%
1–2 days
37 21%
3–7 days
18 10%
1–4 weeks
31 18%
Over a month
22 13%

How the animals did

Recovered
48 26%
Still unwell when reported
88 47%
Died
6 3.2%
Euthanised
11 5.9%
Not known
34 18%

Problems reported at the same time

Age of the animals

Under 1 year
40
1–3 years
51
4–7 years
30
8–11 years
36
12+ years
27

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause urinary incontinence in dogs?
187 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urinary incontinence with similar medicines

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with urinary incontinence