Swelling after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 400 reports of swelling in dogs after Pyrantel + Sarolaner. That is 0.7% of all reports for this medicine, compared with 2.8% across reports for all dog medicines, so it is reported less often than average with this medicine.

400Reports

81%Marked serious

32%Recovered

5.0%Died or euthanised

Same dayTypical onset

How soon it started

Same day

206 53%

1–2 days

81 21%

3–7 days

35 9.0%

1–4 weeks

30 7.7%

Over a month

37 9.5%

How the animals did

Recovered

129 32%

Still unwell when reported

198 50%

Died

11 2.8%

Euthanised

9 2.3%

Not known

53 13%

Problems reported at the same time

160 40%

116 29%

81 20%

70 18%

54 14%

51 13%

27 6.8%

25 6.3%

Age of the animals

Under 1 year

133

1–3 years

136

4–7 years

8–11 years

12+ years

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause swelling in dogs?: 400 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Swelling with similar medicines

Swelling after Febantel + Praziquantel + Pyrantel (Drontal Plus) 87 reports · 1.3% of its reports
Swelling after Fenbendazole 129 reports · 2.2% of its reports
Swelling after Pyrantel 337 reports · 7.0% of its reports
Swelling after Praziquantel + Pyrantel 44 reports · 1.2% of its reports
Swelling after Praziquantel 88 reports · 7.9% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with swelling