Skin rash or irritation after Pyrantel + Sarolaner (Simparica Trio) in dogs

236 reports to the FDA describe skin rash or irritation in dogs given Pyrantel + Sarolaner. That is 0.4% of all reports for this medicine, compared with 1.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

236Reports

64%Marked serious

14%Recovered

0.4%Died or euthanised

3 daysTypical onset

How soon it started

Same day

70 32%

1–2 days

39 18%

3–7 days

37 17%

1–4 weeks

42 19%

Over a month

30 14%

How the animals did

Recovered

34 14%

Still unwell when reported

135 57%

Died

1 0.4%

Not known

66 28%

Problems reported at the same time

Itching

87 37%

Reddening of the skin

29 12%

25 11%

23 9.7%

20 8.5%

18 7.6%

Didn't work as expected

17 7.2%

Allergic reaction

17 7.2%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause skin rash or irritation in dogs?: 236 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin rash or irritation with similar medicines

Skin rash or irritation after Febantel + Praziquantel + Pyrantel (Drontal Plus) 29 reports · 0.4% of its reports
Skin rash or irritation after Fenbendazole 43 reports · 0.7% of its reports
Skin rash or irritation after Pyrantel 27 reports · 0.6% of its reports
Skin rash or irritation after Praziquantel + Pyrantel 24 reports · 0.7% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with skin rash or irritation