Hair loss after Pyrantel + Sarolaner (Simparica Trio) in dogs

231 reports to the FDA describe hair loss in dogs given Pyrantel + Sarolaner. That is 0.4% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported less often than average with this medicine.

231Reports
54%Marked serious
14%Recovered
1.3%Died or euthanised
3 daysTypical onset
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How soon it started

Same day
62 29%
1–2 days
40 19%
3–7 days
29 13%
1–4 weeks
41 19%
Over a month
43 20%

How the animals did

Recovered
31 13%
Recovered with lasting effects
1 0.4%
Still unwell when reported
125 54%
Died
2 0.9%
Euthanised
1 0.4%
Not known
71 31%

Problems reported at the same time

Age of the animals

Under 1 year
37
1–3 years
79
4–7 years
62
8–11 years
25
12+ years
10

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause hair loss in dogs?
231 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 3 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hair loss with similar medicines

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with hair loss