Skin redness after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 205 reports of skin redness in dogs after Pyrantel + Sarolaner. That is 0.4% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported less often than average with this medicine.

205Reports
60%Marked serious
24%Recovered
1.5%Died or euthanised
1 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
93 49%
1–2 days
39 21%
3–7 days
20 11%
1–4 weeks
18 9.5%
Over a month
20 11%

How the animals did

Recovered
49 24%
Recovered with lasting effects
1 0.5%
Still unwell when reported
101 49%
Died
1 0.5%
Euthanised
2 1.0%
Not known
51 25%

Problems reported at the same time

59 29%
40 20%
24 12%
22 11%
21 10%
20 9.8%
20 9.8%

Age of the animals

Under 1 year
30
1–3 years
70
4–7 years
48
8–11 years
41
12+ years
6

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause skin redness in dogs?
205 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin redness with similar medicines

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with skin redness