Reddening of the skin after Pyrantel + Sarolaner (Simparica Trio) in dogs

156 reports to the FDA describe reddening of the skin in dogs given Pyrantel + Sarolaner. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

156Reports

61%Marked serious

23%Recovered

1.3%Died or euthanised

1 daysTypical onset

How soon it started

Same day

66 43%

1–2 days

44 29%

3–7 days

20 13%

1–4 weeks

10 6.5%

Over a month

14 9.1%

How the animals did

Recovered

36 23%

Still unwell when reported

79 51%

Died

1 0.6%

Euthanised

1 0.6%

Not known

39 25%

Problems reported at the same time

Itching

79 51%

Allergic reaction

34 22%

Vomiting

30 19%

Skin rash or irritation

29 19%

23 15%

20 13%

18 12%

16 10%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause reddening of the skin in dogs?: 156 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Reddening of the skin with similar medicines

Reddening of the skin after Pyrantel 28 reports · 0.6% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with reddening of the skin