Skin rash or irritation after Praziquantel + Pyrantel in dogs

The FDA has received 24 reports of skin rash or irritation in dogs after Praziquantel + Pyrantel. That is 0.7% of all reports for this medicine, compared with 1.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

24Reports
46%Marked serious
8.3%Recovered
4.2%Died or euthanised
4 daysTypical onset
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How soon it started

Same day
2 13%
1–2 days
3 20%
3–7 days
5 33%
1–4 weeks
2 13%
Over a month
3 20%

How the animals did

Recovered
2 8.3%
Still unwell when reported
4 17%
Died
1 4.2%
Not known
17 71%

Problems reported at the same time

Vomiting
5 21%
Hair loss
5 21%
Lethargy
4 17%
Itching
4 17%
Skin redness
4 17%
Swelling
3 13%
Loss of appetite
3 13%
Behaviour change
3 13%

Age of the animals

Under 1 year
7
1–3 years
6
4–7 years
7
8–11 years
3
12+ years
1

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause skin rash or irritation in dogs?
24 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 4 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin rash or irritation with similar medicines

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with skin rash or irritation