Pale mucous membrane after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 119 reports of pale mucous membrane in dogs after Pyrantel + Sarolaner. That is 0.2% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported less often than average with this medicine.

119Reports
92%Marked serious
25%Recovered
22%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
50 45%
1–2 days
20 18%
3–7 days
10 9.1%
1–4 weeks
15 14%
Over a month
15 14%

How the animals did

Recovered
30 25%
Still unwell when reported
57 48%
Died
14 12%
Euthanised
12 10%
Not known
6 5.0%

Problems reported at the same time

Age of the animals

Under 1 year
28
1–3 years
41
4–7 years
24
8–11 years
20
12+ years
5

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause pale mucous membrane in dogs?
119 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pale mucous membrane with similar medicines

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with pale mucous membrane