Musculoskeletal disorder after Pyrantel + Sarolaner (Simparica Trio) in dogs

109 reports to the FDA describe musculoskeletal disorder in dogs given Pyrantel + Sarolaner. That is 0.2% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

109Reports

58%Marked serious

21%Recovered

5.5%Died or euthanised

1 daysTypical onset

How soon it started

Same day

46 43%

1–2 days

21 20%

3–7 days

11 10%

1–4 weeks

10 9.4%

Over a month

18 17%

How the animals did

Recovered

23 21%

Still unwell when reported

44 40%

Died

3 2.8%

Euthanised

3 2.8%

Not known

36 33%

Problems reported at the same time

31 28%

30 28%

28 26%

20 18%

16 15%

14 13%

12 11%

12 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause musculoskeletal disorder in dogs?: 109 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with musculoskeletal disorder