Head tilt - neurological disorder after Pyrantel + Sarolaner (Simparica Trio) in dogs

140 reports to the FDA describe head tilt - neurological disorder in dogs given Pyrantel + Sarolaner. That is 0.3% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

140Reports

73%Marked serious

14%Recovered

11%Died or euthanised

2 daysTypical onset

How soon it started

Same day

49 38%

1–2 days

28 22%

3–7 days

16 12%

1–4 weeks

28 22%

Over a month

9 6.9%

How the animals did

Recovered

20 14%

Still unwell when reported

84 60%

Died

3 2.1%

Euthanised

13 9.3%

Not known

20 14%

Problems reported at the same time

54 39%

36 26%

35 25%

35 25%

34 24%

33 24%

22 16%

17 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause head tilt - neurological disorder in dogs?: 140 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with head tilt - neurological disorder