Difficulty going up/down stairs after Pyrantel + Sarolaner (Simparica Trio) in dogs

36 reports to the FDA describe difficulty going up/down stairs in dogs given Pyrantel + Sarolaner. That is 0.1% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

36Reports

64%Marked serious

17%Recovered

17%Died or euthanised

1 daysTypical onset

How soon it started

Same day

16 46%

1–2 days

4 11%

3–7 days

3 8.6%

1–4 weeks

6 17%

Over a month

6 17%

How the animals did

Recovered

6 17%

Still unwell when reported

17 47%

Died

4 11%

Euthanised

2 5.6%

Not known

7 19%

Problems reported at the same time

11 31%

10 28%

7 19%

6 17%

6 17%

6 17%

6 17%

6 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause difficulty going up/down stairs in dogs?: 36 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with difficulty going up/down stairs