Blood in vomit after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 114 reports of blood in vomit in dogs after Pyrantel + Sarolaner. That is 0.2% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

114Reports
64%Marked serious
25%Recovered
6.1%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
53 50%
1–2 days
29 27%
3–7 days
12 11%
1–4 weeks
6 5.7%
Over a month
6 5.7%

How the animals did

Recovered
29 25%
Still unwell when reported
56 49%
Died
4 3.5%
Euthanised
3 2.6%
Not known
22 19%

Problems reported at the same time

Age of the animals

Under 1 year
13
1–3 years
41
4–7 years
32
8–11 years
13
12+ years
8

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause blood in vomit in dogs?
114 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Blood in vomit with similar medicines

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with blood in vomit