Abnormal stool colouration after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 30 reports of abnormal stool colouration in dogs after Pyrantel + Sarolaner. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported less often than average with this medicine.

30Reports
60%Marked serious
27%Recovered
13%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
13 45%
1–2 days
7 24%
3–7 days
4 14%
1–4 weeks
3 10%
Over a month
2 6.9%

How the animals did

Recovered
8 27%
Still unwell when reported
13 43%
Euthanised
4 13%
Not known
5 17%

Problems reported at the same time

Age of the animals

Under 1 year
4
1–3 years
8
4–7 years
8
8–11 years
4
12+ years
5

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause abnormal stool colouration in dogs?
30 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Abnormal stool colouration with similar medicines

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with abnormal stool colouration