Loose stool after Prednisolone + Trimeprazine in dogs

The FDA has received 29 reports of loose stool in dogs after Prednisolone + Trimeprazine. That is 1.4% of all reports for this medicine, compared with 0.9% across reports for all dog medicines, so it is reported unusually often with this medicine.

29Reports

34%Marked serious

14%Recovered

6.9%Died or euthanised

12 daysTypical onset

How soon it started

Same day

3 15%

1–2 days

3 15%

3–7 days

3 15%

1–4 weeks

7 35%

Over a month

4 20%

How the animals did

Recovered

4 14%

Still unwell when reported

13 45%

Died

1 3.4%

Euthanised

1 3.4%

Not known

10 34%

Problems reported at the same time

18 62%

15 52%

13 45%

7 24%

6 21%

Didn't work as expected

6 21%

Diarrhea

5 17%

Fever

4 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisolone + Trimeprazine cause loose stool in dogs?: 29 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 12 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loose stool with similar medicines

Loose stool after Prednisone 149 reports · 1.7% of its reports
Loose stool after Dexamethasone 66 reports · 2.4% of its reports
Loose stool after Prednisolone 20 reports · 1.7% of its reports

All reported side effects of Prednisolone + Trimeprazine in dogs · Medicines most reported with loose stool