Inappropriate defecation after Praziquantel + Pyrantel in dogs

34 reports to the FDA describe inappropriate defecation in dogs given Praziquantel + Pyrantel. That is 0.9% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

34Reports

47%Marked serious

32%Recovered

8.8%Died or euthanised

Same dayTypical onset

How soon it started

Same day

20 63%

1–2 days

10 31%

3–7 days

1 3.1%

1–4 weeks

1 3.1%

Over a month

0 0.0%

How the animals did

Recovered

11 32%

Still unwell when reported

1 2.9%

Died

3 8.8%

Not known

19 56%

Problems reported at the same time

20 59%

12 35%

10 29%

7 21%

5 15%

4 12%

3 8.8%

3 8.8%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause inappropriate defecation in dogs?: 34 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Inappropriate defecation with similar medicines

Inappropriate defecation after Pyrantel + Sarolaner (Simparica Trio) 85 reports · 0.2% of its reports
Inappropriate defecation after Febantel + Praziquantel + Pyrantel (Drontal Plus) 20 reports · 0.3% of its reports

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with inappropriate defecation