Inappropriate defecation after Febantel + Praziquantel + Pyrantel (Drontal Plus) in dogs

The FDA has received 20 reports of inappropriate defecation in dogs after Febantel + Praziquantel + Pyrantel. That is 0.3% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

20Reports
35%Marked serious
20%Recovered
10%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
10 56%
1–2 days
3 17%
3–7 days
0 0.0%
1–4 weeks
2 11%
Over a month
3 17%

How the animals did

Recovered
4 20%
Still unwell when reported
2 10%
Died
1 5.0%
Euthanised
1 5.0%
Not known
12 60%

Problems reported at the same time

Age of the animals

Under 1 year
10
1–3 years
3
4–7 years
2
8–11 years
2
12+ years
2

About this medicine

Febantel treats intestinal worms. Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Drontal Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Febantel + Praziquantel + Pyrantel cause inappropriate defecation in dogs?
20 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Inappropriate defecation with similar medicines

All reported side effects of Febantel + Praziquantel + Pyrantel in dogs · Medicines most reported with inappropriate defecation