Dehydration after Praziquantel + Pyrantel in dogs

20 reports to the FDA describe dehydration in dogs given Praziquantel + Pyrantel. That is 0.5% of all reports for this medicine, compared with 0.7% across reports for all dog medicines.

20Reports

80%Marked serious

25%Recovered

30%Died or euthanised

1 daysTypical onset

How soon it started

Same day

7 37%

1–2 days

8 42%

3–7 days

3 16%

1–4 weeks

1 5.3%

Over a month

0 0.0%

How the animals did

Recovered

5 25%

Still unwell when reported

1 5.0%

Died

4 20%

Euthanised

2 10%

Not known

8 40%

Problems reported at the same time

14 70%

11 55%

11 55%

8 40%

5 25%

3 15%

3 15%

2 10%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause dehydration in dogs?: 20 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Dehydration with similar medicines

Dehydration after Pyrantel + Sarolaner (Simparica Trio) 212 reports · 0.4% of its reports
Dehydration after Febantel + Praziquantel + Pyrantel (Drontal Plus) 44 reports · 0.7% of its reports
Dehydration after Fenbendazole 97 reports · 1.6% of its reports
Dehydration after Pyrantel 75 reports · 1.6% of its reports

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with dehydration