Dehydration after Febantel + Praziquantel + Pyrantel (Drontal Plus) in dogs

The FDA has received 44 reports of dehydration in dogs after Febantel + Praziquantel + Pyrantel. That is 0.7% of all reports for this medicine, compared with 0.7% across reports for all dog medicines.

44Reports
68%Marked serious
34%Recovered
9.1%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
19 49%
1–2 days
4 10%
3–7 days
6 15%
1–4 weeks
7 18%
Over a month
3 7.7%

How the animals did

Recovered
15 34%
Still unwell when reported
10 23%
Died
3 6.8%
Euthanised
1 2.3%
Not known
15 34%

Problems reported at the same time

Vomiting
28 64%
Lethargy
20 45%
Loss of appetite
20 45%
Diarrhea
12 27%
Liver problems
10 23%
Kidney problems
10 23%
Breathing problems
7 16%
Fever
6 14%

Age of the animals

Under 1 year
21
1–3 years
8
4–7 years
6
8–11 years
7
12+ years
2

About this medicine

Febantel treats intestinal worms. Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Drontal Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Febantel + Praziquantel + Pyrantel cause dehydration in dogs?
44 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Dehydration with similar medicines

All reported side effects of Febantel + Praziquantel + Pyrantel in dogs · Medicines most reported with dehydration