Kidney problems after Febantel + Praziquantel + Pyrantel (Drontal Plus) in dogs

The FDA has received 55 reports of kidney problems in dogs after Febantel + Praziquantel + Pyrantel. That is 0.8% of all reports for this medicine, compared with 2.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

55Reports
65%Marked serious
9.1%Recovered
29%Died or euthanised
2 daysTypical onset
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How soon it started

Same day
14 36%
1–2 days
6 15%
3–7 days
5 13%
1–4 weeks
7 18%
Over a month
7 18%

How the animals did

Recovered
4 7.3%
Recovered with lasting effects
1 1.8%
Still unwell when reported
9 16%
Died
8 15%
Euthanised
8 15%
Not known
25 45%

Problems reported at the same time

Age of the animals

Under 1 year
24
1–3 years
7
4–7 years
6
8–11 years
6
12+ years
10

About this medicine

Febantel treats intestinal worms. Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Drontal Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Febantel + Praziquantel + Pyrantel cause kidney problems in dogs?
55 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 2 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

All reported side effects of Febantel + Praziquantel + Pyrantel in dogs · Medicines most reported with kidney problems