Wobbliness (ataxia) after Polysulfated Glycosaminoglycan in dogs

The FDA has received 150 reports of wobbliness (ataxia) in dogs after Polysulfated Glycosaminoglycan. That is 2.7% of all reports for this medicine, compared with 2.6% across reports for all dog medicines.

150Reports

53%Marked serious

23%Recovered

21%Died or euthanised

14 daysTypical onset

How soon it started

Same day

23 26%

1–2 days

7 7.8%

3–7 days

9 10%

1–4 weeks

15 17%

Over a month

36 40%

How the animals did

Recovered

32 21%

Recovered with lasting effects

3 2.0%

Still unwell when reported

41 27%

Died

16 11%

Euthanised

16 11%

Not known

42 28%

Problems reported at the same time

39 26%

34 23%

32 21%

32 21%

29 19%

22 15%

Proprioception deficit

20 13%

Breathing problems

19 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause wobbliness (ataxia) in dogs?: 150 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 14 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Wobbliness (ataxia) with similar medicines

Wobbliness (ataxia) after Melarsomine (Immiticide) 599 reports · 2.6% of its reports
Wobbliness (ataxia) after Diphenhydramine 169 reports · 3.6% of its reports
Wobbliness (ataxia) after Butorphanol 125 reports · 2.8% of its reports
Wobbliness (ataxia) after Cefpodoxime 182 reports · 4.5% of its reports
Wobbliness (ataxia) after Tramadol 168 reports · 4.5% of its reports
Wobbliness (ataxia) after Florfenicol + Mometasone + Terbinafine 430 reports · 12% of its reports
Wobbliness (ataxia) after Desoxycorticosterone Pivalate 33 reports · 1.0% of its reports
Wobbliness (ataxia) after Propofol 69 reports · 2.2% of its reports
Wobbliness (ataxia) after Dirlotapide 23 reports · 0.8% of its reports
Wobbliness (ataxia) after Isoflurane 81 reports · 2.9% of its reports

All reported side effects of Polysulfated Glycosaminoglycan in dogs · Medicines most reported with wobbliness (ataxia)