Proprioception deficit after Polysulfated Glycosaminoglycan in dogs

The FDA has received 51 reports of proprioception deficit in dogs after Polysulfated Glycosaminoglycan. That is 0.9% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

51Reports

86%Marked serious

3.9%Recovered

35%Died or euthanised

28 daysTypical onset

How soon it started

Same day

6 17%

1–2 days

4 11%

3–7 days

1 2.8%

1–4 weeks

8 22%

Over a month

17 47%

How the animals did

Recovered

2 3.9%

Still unwell when reported

23 45%

Died

3 5.9%

Euthanised

15 29%

Not known

8 16%

Problems reported at the same time

23 45%

20 39%

18 35%

13 25%

13 25%

11 22%

10 20%

Abnormal radiograph finding

10 20%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause proprioception deficit in dogs?: 51 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 28 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Proprioception deficit with similar medicines

Proprioception deficit after Melarsomine (Immiticide) 47 reports · 0.2% of its reports
Proprioception deficit after Cefpodoxime 24 reports · 0.6% of its reports
Proprioception deficit after Tramadol 42 reports · 1.1% of its reports
Proprioception deficit after Famotidine 20 reports · 0.8% of its reports
Proprioception deficit after Chondroitin + Glucosamine 39 reports · 1.5% of its reports
Proprioception deficit after Glucosamine 32 reports · 1.8% of its reports
Proprioception deficit after Fish Oil 20 reports · 1.3% of its reports
Proprioception deficit after Methocarbamol 23 reports · 3.7% of its reports
Proprioception deficit after Amantadine 28 reports · 5.5% of its reports
Proprioception deficit after Dasuquin 25 reports · 5.9% of its reports

All reported side effects of Polysulfated Glycosaminoglycan in dogs · Medicines most reported with proprioception deficit