Neutropenia after Polysulfated Glycosaminoglycan in dogs

The FDA has received 34 reports of neutropenia in dogs after Polysulfated Glycosaminoglycan. That is 0.6% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

34Reports
71%Marked serious
18%Recovered
12%Died or euthanised
35 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
3 13%
1–2 days
1 4.3%
3–7 days
0 0.0%
1–4 weeks
5 22%
Over a month
14 61%

How the animals did

Recovered
6 18%
Still unwell when reported
13 38%
Euthanised
4 12%
Not known
11 32%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
5
8–11 years
17
12+ years
10

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause neutropenia in dogs?
34 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 35 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neutropenia with similar medicines

All reported side effects of Polysulfated Glycosaminoglycan in dogs · Medicines most reported with neutropenia