Musculoskeletal disorder after Polysulfated Glycosaminoglycan in dogs

67 reports to the FDA describe musculoskeletal disorder in dogs given Polysulfated Glycosaminoglycan. That is 1.2% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

67Reports

60%Marked serious

16%Recovered

19%Died or euthanised

35 daysTypical onset

How soon it started

Same day

9 22%

1–2 days

2 4.9%

3–7 days

3 7.3%

1–4 weeks

4 9.8%

Over a month

23 56%

How the animals did

Recovered

10 15%

Recovered with lasting effects

1 1.5%

Still unwell when reported

19 28%

Died

2 3.0%

Euthanised

11 16%

Not known

24 36%

Problems reported at the same time

16 24%

15 22%

13 19%

12 18%

12 18%

11 16%

11 16%

Abnormal radiograph finding

11 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause musculoskeletal disorder in dogs?: 67 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 35 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Musculoskeletal disorder with similar medicines

Musculoskeletal disorder after Melarsomine (Immiticide) 78 reports · 0.3% of its reports
Musculoskeletal disorder after Diphenhydramine 33 reports · 0.7% of its reports
Musculoskeletal disorder after Butorphanol 23 reports · 0.5% of its reports
Musculoskeletal disorder after Cefpodoxime 31 reports · 0.8% of its reports
Musculoskeletal disorder after Tramadol 87 reports · 2.3% of its reports
Musculoskeletal disorder after Desoxycorticosterone Pivalate 20 reports · 0.6% of its reports
Musculoskeletal disorder after Propofol 24 reports · 0.8% of its reports
Musculoskeletal disorder after Famotidine 49 reports · 1.9% of its reports
Musculoskeletal disorder after Chondroitin + Glucosamine 54 reports · 2.1% of its reports
Musculoskeletal disorder after Glucosamine 46 reports · 2.5% of its reports

All reported side effects of Polysulfated Glycosaminoglycan in dogs · Medicines most reported with musculoskeletal disorder