Lameness after Polysulfated Glycosaminoglycan in dogs

The FDA has received 181 reports of lameness in dogs after Polysulfated Glycosaminoglycan. That is 3.3% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

181Reports
38%Marked serious
16%Recovered
10%Died or euthanised
12 daysTypical onset
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How soon it started

Same day
19 21%
1–2 days
12 13%
3–7 days
10 11%
1–4 weeks
18 20%
Over a month
33 36%

How the animals did

Recovered
26 14%
Recovered with lasting effects
3 1.7%
Still unwell when reported
50 28%
Died
9 5.0%
Euthanised
10 5.5%
Not known
83 46%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
10
4–7 years
26
8–11 years
80
12+ years
56

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause lameness in dogs?
181 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 12 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lameness with similar medicines

All reported side effects of Polysulfated Glycosaminoglycan in dogs · Medicines most reported with lameness