Heart murmur after Phenylpropanolamine (Proin) in dogs

23 reports to the FDA describe heart murmur in dogs given Phenylpropanolamine. That is 0.6% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

23Reports

87%Marked serious

26%Recovered

13%Died or euthanised

1 daysTypical onset

How soon it started

Same day

7 47%

1–2 days

1 6.7%

3–7 days

2 13%

1–4 weeks

2 13%

Over a month

3 20%

How the animals did

Recovered

5 22%

Recovered with lasting effects

1 4.3%

Still unwell when reported

9 39%

Euthanised

3 13%

Not known

5 22%

Problems reported at the same time

9 39%

7 30%

6 26%

6 26%

5 22%

4 17%

4 17%

4 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause heart murmur in dogs?: 23 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Heart murmur with similar medicines

Heart murmur after Trilostane (Vetoryl) 159 reports · 1.3% of its reports
Heart murmur after Insulin 47 reports · 0.6% of its reports
Heart murmur after Levothyroxine 27 reports · 0.9% of its reports

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with heart murmur