Fever after Phenylpropanolamine (Proin) in dogs

The FDA has received 94 reports of fever in dogs after Phenylpropanolamine. That is 2.3% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

94Reports

85%Marked serious

46%Recovered

19%Died or euthanised

Same dayTypical onset

How soon it started

Same day

45 69%

1–2 days

4 6.2%

3–7 days

3 4.6%

1–4 weeks

3 4.6%

Over a month

10 15%

How the animals did

Recovered

42 45%

Recovered with lasting effects

1 1.1%

Still unwell when reported

14 15%

Died

6 6.4%

Euthanised

12 13%

Not known

19 20%

Problems reported at the same time

Vomiting

40 43%

Restlessness or agitation

34 36%

32 34%

28 30%

24 26%

24 26%

22 23%

20 21%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause fever in dogs?: 94 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Fever with similar medicines

Fever after Trilostane (Vetoryl) 81 reports · 0.7% of its reports
Fever after Insulin 53 reports · 0.7% of its reports
Fever after Levothyroxine 50 reports · 1.7% of its reports

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with fever