Bradycardia after Phenylpropanolamine (Proin) in dogs

The FDA has received 83 reports of bradycardia in dogs after Phenylpropanolamine. That is 2.0% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

83Reports

88%Marked serious

72%Recovered

1.2%Died or euthanised

Same dayTypical onset

How soon it started

Same day

60 87%

1–2 days

4 5.8%

3–7 days

0 0.0%

1–4 weeks

1 1.4%

Over a month

4 5.8%

How the animals did

Recovered

60 72%

Still unwell when reported

5 6.0%

Euthanised

1 1.2%

Not known

17 20%

Problems reported at the same time

Hypertension

46 55%

Vomiting

40 48%

Accidental exposure

38 46%

Eye or vision problems

23 28%

Restlessness or agitation

23 28%

Breathing problems

22 27%

Lethargy

21 25%

Piloerection

20 24%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause bradycardia in dogs?: 83 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Bradycardia with similar medicines

Bradycardia after Trilostane (Vetoryl) 35 reports · 0.3% of its reports

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with bradycardia