Bradycardia after Trilostane (Vetoryl) in dogs

35 reports to the FDA describe bradycardia in dogs given Trilostane. That is 0.3% of all reports for this medicine, compared with 0.3% across reports for all dog medicines.

35Reports

91%Marked serious

11%Recovered

29%Died or euthanised

48 daysTypical onset

How soon it started

Same day

4 14%

1–2 days

1 3.6%

3–7 days

1 3.6%

1–4 weeks

5 18%

Over a month

17 61%

How the animals did

Recovered

4 11%

Still unwell when reported

11 31%

Died

4 11%

Euthanised

6 17%

Not known

10 29%

Problems reported at the same time

17 49%

16 46%

15 43%

13 37%

12 34%

11 31%

Abnormal adrenocorticotropic hormone (acth) stimulation test

11 31%

Death

10 29%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause bradycardia in dogs?: 35 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 48 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Bradycardia with similar medicines

Bradycardia after Phenylpropanolamine (Proin) 83 reports · 2.0% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with bradycardia