Urinary incontinence after Oclacitinib (Apoquel) in dogs

The FDA has received 281 reports of urinary incontinence in dogs after Oclacitinib. That is 1.0% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

281Reports
37%Marked serious
17%Recovered
9.6%Died or euthanised
20 daysTypical onset
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How soon it started

Same day
46 22%
1–2 days
22 11%
3–7 days
18 8.7%
1–4 weeks
33 16%
Over a month
89 43%

How the animals did

Recovered
47 17%
Recovered with lasting effects
1 0.4%
Still unwell when reported
158 56%
Died
7 2.5%
Euthanised
20 7.1%
Not known
48 17%

Problems reported at the same time

Age of the animals

Under 1 year
3
1–3 years
37
4–7 years
77
8–11 years
87
12+ years
68

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause urinary incontinence in dogs?
281 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 20 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urinary incontinence with similar medicines

All reported side effects of Oclacitinib in dogs · Medicines most reported with urinary incontinence