Urinary tract infection after Oclacitinib (Apoquel) in dogs

The FDA has received 436 reports of urinary tract infection in dogs after Oclacitinib. That is 1.5% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

436Reports
45%Marked serious
10%Recovered
8.7%Died or euthanised
45 daysTypical onset
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How soon it started

Same day
27 9.3%
1–2 days
10 3.5%
3–7 days
23 8.0%
1–4 weeks
56 19%
Over a month
173 60%

How the animals did

Recovered
44 10%
Recovered with lasting effects
1 0.2%
Still unwell when reported
293 67%
Died
8 1.8%
Euthanised
30 6.9%
Not known
60 14%

Problems reported at the same time

Age of the animals

Under 1 year
4
1–3 years
45
4–7 years
135
8–11 years
169
12+ years
67

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause urinary tract infection in dogs?
436 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 45 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urinary tract infection with similar medicines

All reported side effects of Oclacitinib in dogs · Medicines most reported with urinary tract infection