Excessive urination after Oclacitinib (Apoquel) in dogs

The FDA has received 648 reports of excessive urination in dogs after Oclacitinib. That is 2.2% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

648Reports
35%Marked serious
9.3%Recovered
6.2%Died or euthanised
21 daysTypical onset
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How soon it started

Same day
82 16%
1–2 days
42 8.5%
3–7 days
45 9.1%
1–4 weeks
108 22%
Over a month
220 44%

How the animals did

Recovered
60 9.3%
Still unwell when reported
466 72%
Died
14 2.2%
Euthanised
26 4.0%
Not known
82 13%

Problems reported at the same time

Age of the animals

Under 1 year
7
1–3 years
82
4–7 years
196
8–11 years
232
12+ years
112

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause excessive urination in dogs?
648 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 21 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive urination with similar medicines

All reported side effects of Oclacitinib in dogs · Medicines most reported with excessive urination