Excessive thirst after Oclacitinib (Apoquel) in dogs

794 reports to the FDA describe excessive thirst in dogs given Oclacitinib. That is 2.7% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

794Reports
34%Marked serious
11%Recovered
6.0%Died or euthanised
22 daysTypical onset
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How soon it started

Same day
103 18%
1–2 days
51 8.7%
3–7 days
61 10%
1–4 weeks
111 19%
Over a month
261 44%

How the animals did

Recovered
83 10%
Recovered with lasting effects
2 0.3%
Still unwell when reported
549 69%
Died
14 1.8%
Euthanised
34 4.3%
Not known
112 14%

Problems reported at the same time

Age of the animals

Under 1 year
7
1–3 years
99
4–7 years
246
8–11 years
286
12+ years
134

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause excessive thirst in dogs?
794 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 22 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive thirst with similar medicines

All reported side effects of Oclacitinib in dogs · Medicines most reported with excessive thirst