Urinary incontinence after Cyclosporine (Atopica) in dogs

The FDA has received 140 reports of urinary incontinence in dogs after Cyclosporine. That is 0.9% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

140Reports
16%Marked serious
7.9%Recovered
9.3%Died or euthanised
18 daysTypical onset
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How soon it started

Same day
3 13%
1–2 days
2 8.7%
3–7 days
5 22%
1–4 weeks
2 8.7%
Over a month
11 48%

How the animals did

Recovered
8 5.7%
Recovered with lasting effects
3 2.1%
Still unwell when reported
15 11%
Died
11 7.9%
Euthanised
2 1.4%
Not known
101 72%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
27
4–7 years
42
8–11 years
38
12+ years
32

About this medicine

Cyclosporine controls allergic skin disease and some immune conditions.

Products with this ingredient include Atopica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Cyclosporine cause urinary incontinence in dogs?
140 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 18 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urinary incontinence with similar medicines

All reported side effects of Cyclosporine in dogs · Medicines most reported with urinary incontinence